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The total leukocyte count in
normal blood ranges from 5,000 to 10,000 white cells per cubic
millimeter. The term Leukocytosis signifies an abnormal increase in the number of circulating white blood cells.
The term Leukopenia signifies an abnormal decrease in the number of white blood cells to fewer than 5,000 cells per cubic millimeter.
In general, a leukocytosis may be regarded as a response of
the bone marrow to an increased demand of leukocytes. The
degree and type of response vary (1) with the intensity of the
stimulus (which depends largely on the species of the
infecting organism, on its virulence and on the location &
extent of the area involved) (2) on the reacting power of the
individual. A mild infection may call forth for an
insignificant response. If the infection is overwhelming or
the reacting power of the marrow id seriously impaired, there
may be no leukocytosis but even a leukopenia.
In interpreting the
leukocytic response to an infection however changes in
differential count and qualitative alterations in leukocytes
are more significant than an increase in their total number.
The following table show their rise and fall inn different
diseases & infections:
|
Leukocytes |
Normal
Range |
Increased
In |
Diminished
In |
| Neutrophiles |
40 - 75 % |
All kinds of
infections & inflammations specially septic
conditions, very markedly in myeloid leukemia. |
Kala Azar
markedly and slightly in Malaria, TB, Typhoid Fever,
Whooping Cough, Pernicious & Aplastic anemia. |
| Lymphocytes |
20-45 % |
Early stage of
Chickenpox, measles, typhus, whooping cough, brocho-pneumonia,
malaria and glandular fevers. During convalescence from
any acute infection. In some cases of TB. Markedly in
Kala Azar, typhoid fever, bacillary dysentery, mumps and
brucella infections, secondary syphilis, hyperthyroidism,
after exposure to ultra violet radiations and in lymphatic
leukemia. |
Absolute
number after excessive radiation, during the acute stage
of most infections, in conditions in which the lymphoid
tissue is replaced by other tissue as in myelogenous
leukemia, advanced Hodgkin's disease, extensive TB or
carcinomatosis of the lymph glands and in conditions
with marked increase of polymorpho- nuclear. |
| Monocytes |
Up to 8 % |
Many cases of
malaria and other protozoal infections including
trypano-somiasis, kala azar and ameobiasis. Less
regularly and often only in slight degree in variola,
typhus, spotted fever, dengue, yellow fever, measles,
syphilis, bacterial endocarditis, active progressive TB,
Hodgkin's disease, monocytic leukemia, banti's disease. |
Acute
inflammation with marked increase of polymorpho -
neuclears. |
| Eosinophils |
1 - 6 % |
Intestinal parasites,
skin diseases, asthma, hay fever, urticaria, gonorrhea, epidemic
dropsy, dengue, Hodgkin's disease and myeloid leukemia. |
Acute phase of
most severe infections. |
| Basophiles |
Up to 1 % |
Chronic
myeloid leukemia and alcoholic jaundice, and erythraemia. |
Nil |
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